Gubatan Lab · Mayo Clinic

The rules of intestinal immunity

Our science

Why does a protective
response become
persistent inflammation?

Our laboratory studies how immune cells and gut microbes interact in inflammatory bowel disease. We connect questions from patients with molecular discovery, computational models and experiments that test mechanisms.

Explore our research questions

Recent discoveries

From the lab

Selected publications

Cell Reports Medicine · 2026

Vitamin D and the
immune–microbiome dialogue

Our multi-omics study connects vitamin D treatment with changes in antibody-coated gut bacteria and immune pathways associated with tolerance in inflammatory bowel disease.

Read the study

Preprint · September 2026

Connecting immune history to cell behavior

A single-cell blood atlas links B- and T-cell receptor features to coordinated immune programs in inflammatory bowel disease, creating a resource for studying adaptive immune states.

Read the preprint

Preprint · September 2026

How intestinal support cells shape inflammation

Human tissue profiling, spatial imaging and experimental models connect the local fibroblast environment to neutrophil behavior in ulcerative colitis.

Read the preprint

People behind the questions

Different perspectives.
A shared curiosity.

Our team connects clinical insight, experimental biology and computational analysis to understand intestinal inflammation.

Meet the team